Endocrine Abstracts

Among the different functions of bone, the biomechanical one is the most evident. Biomechanical function of bone allows locomotion and protection of essential organs like brain and in a way can be considered as a survival function. Optimal bone strength maintenance through bone remodeling is an active energy consuming process. When a fracture occurs, two sides of the phenomenon should be evaluated: the trauma and the bone resistance including bone mass and bone quality. Bone r...

Background: Klinefelter Syndrome (KS) patients, defined by a 47 XXY karyotype, suffer from osteoporosis, with an increased risk of mortality after femoral neck fracture. The mechanisms underlying this bone alteration remain unclear.Patients and methods: In KS patients naïve from testosterone substitution therapy (TST), we assessed bone microarchitecture at distal radius and tibia by High Resolution peripheral Computed Quantitative Tomography, and bo...